AustralieFrV1, Main, Exploration, bibRecord, 000828

Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.

Identifieur interne : 000828 ( Main/Exploration ); précédent : 000827; suivant : 000829

Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.

Auteurs : R J Edmondson [Royaume-Uni] ; E J Crosbie [Royaume-Uni] ; M. Nickkho-Amiry [Royaume-Uni] ; A. Kaufmann [Royaume-Uni] ; E. Stelloo ; H W Nijman [Pays-Bas] ; A. Leary [France] ; A. Auguste [France] ; L. Mileshkin [Australie] ; P. Pollock [Australie] ; H J Mackay [Canada] ; M E Powell [Royaume-Uni] ; T. Bosse ; C L Creutzberg [Pays-Bas] ; H C Kitchener [Royaume-Uni]

Source :

Gynecologic oncology [ 1095-6859 ] ; 2017.

RBID : pubmed:28511869

Descripteurs français

English descriptors

Abstract

The morphological classification of high-risk endometrial cancer is of limited prognostic value. Recent attempts to stratify tumours according to molecular signatures have shown considerable promise. Here we attempted to further refine molecular classifications using markers of the p53 pathway.

DOI: 10.1016/j.ygyno.2017.05.014
PubMed: 28511869

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.</title>
<author><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester, UK. Electronic address: richard.edmondson@manchester.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Crosbie, E J" sort="Crosbie, E J" uniqKey="Crosbie E" first="E J" last="Crosbie">E J Crosbie</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Nickkho Amiry, M" sort="Nickkho Amiry, M" uniqKey="Nickkho Amiry M" first="M" last="Nickkho-Amiry">M. Nickkho-Amiry</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Kaufmann, A" sort="Kaufmann, A" uniqKey="Kaufmann A" first="A" last="Kaufmann">A. Kaufmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Northern Institute of Cancer Research, Newcastle University, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Northern Institute of Cancer Research, Newcastle University</wicri:regionArea>
<wicri:noRegion>Newcastle University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stelloo, E" sort="Stelloo, E" uniqKey="Stelloo E" first="E" last="Stelloo">E. Stelloo</name>
<affiliation><nlm:affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherland.</nlm:affiliation>
<wicri:noCountry code="subField">The Netherland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nijman, H W" sort="Nijman, H W" uniqKey="Nijman H" first="H W" last="Nijman">H W Nijman</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Leary, A" sort="Leary, A" uniqKey="Leary A" first="A" last="Leary">A. Leary</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Auguste, A" sort="Auguste, A" uniqKey="Auguste A" first="A" last="Auguste">A. Auguste</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mileshkin, L" sort="Mileshkin, L" uniqKey="Mileshkin L" first="L" last="Mileshkin">L. Mileshkin</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne</wicri:regionArea>
<wicri:noRegion>East Melbourne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollock, P" sort="Pollock, P" uniqKey="Pollock P" first="P" last="Pollock">P. Pollock</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland University of Technology, (QUT), Translational Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland University of Technology, (QUT), Translational Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackay, H J" sort="Mackay, H J" uniqKey="Mackay H" first="H J" last="Mackay">H J Mackay</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto</wicri:regionArea>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Powell, M E" sort="Powell, M E" uniqKey="Powell M" first="M E" last="Powell">M E Powell</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Barts Health NHS Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Barts Health NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bosse, T" sort="Bosse, T" uniqKey="Bosse T" first="T" last="Bosse">T. Bosse</name>
<affiliation><nlm:affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherland.</nlm:affiliation>
<wicri:noCountry code="subField">The Netherland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Creutzberg, C L" sort="Creutzberg, C L" uniqKey="Creutzberg C" first="C L" last="Creutzberg">C L Creutzberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Oncology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kitchener, H C" sort="Kitchener, H C" uniqKey="Kitchener H" first="H C" last="Kitchener">H C Kitchener</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28511869</idno>
<idno type="pmid">28511869</idno>
<idno type="doi">10.1016/j.ygyno.2017.05.014</idno>
<idno type="wicri:Area/PubMed/Corpus">000741</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000741</idno>
<idno type="wicri:Area/PubMed/Curation">000738</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000738</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000738</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000738</idno>
<idno type="wicri:Area/Ncbi/Merge">004827</idno>
<idno type="wicri:Area/Ncbi/Curation">004827</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004827</idno>
<idno type="wicri:Area/Main/Merge">000823</idno>
<idno type="wicri:Area/Main/Curation">000828</idno>
<idno type="wicri:Area/Main/Exploration">000828</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.</title>
<author><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester, UK. Electronic address: richard.edmondson@manchester.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Crosbie, E J" sort="Crosbie, E J" uniqKey="Crosbie E" first="E J" last="Crosbie">E J Crosbie</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK; Department of Obstetrics and Gynaecology, Manchester Academic Health Science Centre, St Mary's Hospital, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Level 5, Research, Oxford Road, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Nickkho Amiry, M" sort="Nickkho Amiry, M" uniqKey="Nickkho Amiry M" first="M" last="Nickkho-Amiry">M. Nickkho-Amiry</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Kaufmann, A" sort="Kaufmann, A" uniqKey="Kaufmann A" first="A" last="Kaufmann">A. Kaufmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Northern Institute of Cancer Research, Newcastle University, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Northern Institute of Cancer Research, Newcastle University</wicri:regionArea>
<wicri:noRegion>Newcastle University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stelloo, E" sort="Stelloo, E" uniqKey="Stelloo E" first="E" last="Stelloo">E. Stelloo</name>
<affiliation><nlm:affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherland.</nlm:affiliation>
<wicri:noCountry code="subField">The Netherland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nijman, H W" sort="Nijman, H W" uniqKey="Nijman H" first="H W" last="Nijman">H W Nijman</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Leary, A" sort="Leary, A" uniqKey="Leary A" first="A" last="Leary">A. Leary</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Auguste, A" sort="Auguste, A" uniqKey="Auguste A" first="A" last="Auguste">A. Auguste</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U981, Department of Medicine, Gynecology Unit, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mileshkin, L" sort="Mileshkin, L" uniqKey="Mileshkin L" first="L" last="Mileshkin">L. Mileshkin</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne</wicri:regionArea>
<wicri:noRegion>East Melbourne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollock, P" sort="Pollock, P" uniqKey="Pollock P" first="P" last="Pollock">P. Pollock</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland University of Technology, (QUT), Translational Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland University of Technology, (QUT), Translational Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackay, H J" sort="Mackay, H J" uniqKey="Mackay H" first="H J" last="Mackay">H J Mackay</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto</wicri:regionArea>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Powell, M E" sort="Powell, M E" uniqKey="Powell M" first="M E" last="Powell">M E Powell</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Barts Health NHS Trust, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Oncology, Barts Health NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bosse, T" sort="Bosse, T" uniqKey="Bosse T" first="T" last="Bosse">T. Bosse</name>
<affiliation><nlm:affiliation>Department of Pathology, Leiden University Medical Center, Leiden, The Netherland.</nlm:affiliation>
<wicri:noCountry code="subField">The Netherland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Creutzberg, C L" sort="Creutzberg, C L" uniqKey="Creutzberg C" first="C L" last="Creutzberg">C L Creutzberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Oncology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kitchener, H C" sort="Kitchener, H C" uniqKey="Kitchener H" first="H C" last="Kitchener">H C Kitchener</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Gynecologic oncology</title>
<idno type="eISSN">1095-6859</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma, Clear Cell (genetics)</term>
<term>Adenocarcinoma, Clear Cell (metabolism)</term>
<term>Adenocarcinoma, Clear Cell (mortality)</term>
<term>Adenocarcinoma, Clear Cell (pathology)</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Carcinoma, Endometrioid (genetics)</term>
<term>Carcinoma, Endometrioid (metabolism)</term>
<term>Carcinoma, Endometrioid (mortality)</term>
<term>Carcinoma, Endometrioid (pathology)</term>
<term>Cell Line, Tumor</term>
<term>Cyclin-Dependent Kinase Inhibitor p21 (metabolism)</term>
<term>Endometrial Neoplasms (genetics)</term>
<term>Endometrial Neoplasms (metabolism)</term>
<term>Endometrial Neoplasms (mortality)</term>
<term>Endometrial Neoplasms (pathology)</term>
<term>Female</term>
<term>Gene Silencing</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Invasiveness</term>
<term>Neoplasms, Cystic, Mucinous, and Serous (genetics)</term>
<term>Neoplasms, Cystic, Mucinous, and Serous (metabolism)</term>
<term>Neoplasms, Cystic, Mucinous, and Serous (mortality)</term>
<term>Neoplasms, Cystic, Mucinous, and Serous (pathology)</term>
<term>Phosphoproteins</term>
<term>Prognosis</term>
<term>Proportional Hazards Models</term>
<term>Proto-Oncogene Proteins c-mdm2 (metabolism)</term>
<term>Signal Transduction</term>
<term>Transcription Factors (metabolism)</term>
<term>Tumor Suppressor Protein p53 (genetics)</term>
<term>Tumor Suppressor Protein p53 (metabolism)</term>
<term>Tumor Suppressor Proteins (metabolism)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Adénocarcinome à cellules claires (anatomopathologie)</term>
<term>Adénocarcinome à cellules claires (génétique)</term>
<term>Adénocarcinome à cellules claires (mortalité)</term>
<term>Adénocarcinome à cellules claires (métabolisme)</term>
<term>Carcinome endométrioïde (anatomopathologie)</term>
<term>Carcinome endométrioïde (génétique)</term>
<term>Carcinome endométrioïde (mortalité)</term>
<term>Carcinome endométrioïde (métabolisme)</term>
<term>Extinction de l'expression des gènes</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Femelle</term>
<term>Grading des tumeurs</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Inhibiteur p21 de kinase cycline-dépendante (métabolisme)</term>
<term>Invasion tumorale</term>
<term>Jeune adulte</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles de hasards proportionnels</term>
<term>Mutation</term>
<term>Phosphoprotéines</term>
<term>Pronostic</term>
<term>Protéine p53 suppresseur de tumeur (génétique)</term>
<term>Protéine p53 suppresseur de tumeur (métabolisme)</term>
<term>Protéines proto-oncogènes c-mdm2 (métabolisme)</term>
<term>Protéines suppresseurs de tumeurs (métabolisme)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transduction du signal</term>
<term>Tumeurs de l'endomètre (anatomopathologie)</term>
<term>Tumeurs de l'endomètre (génétique)</term>
<term>Tumeurs de l'endomètre (mortalité)</term>
<term>Tumeurs de l'endomètre (métabolisme)</term>
<term>Tumeurs kystiques, mucineuses et séreuses (anatomopathologie)</term>
<term>Tumeurs kystiques, mucineuses et séreuses (génétique)</term>
<term>Tumeurs kystiques, mucineuses et séreuses (mortalité)</term>
<term>Tumeurs kystiques, mucineuses et séreuses (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Tumor Suppressor Protein p53</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclin-Dependent Kinase Inhibitor p21</term>
<term>Proto-Oncogene Proteins c-mdm2</term>
<term>Transcription Factors</term>
<term>Tumor Suppressor Protein p53</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome à cellules claires</term>
<term>Carcinome endométrioïde</term>
<term>Tumeurs de l'endomètre</term>
<term>Tumeurs kystiques, mucineuses et séreuses</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
<term>Neoplasms, Cystic, Mucinous, and Serous</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome à cellules claires</term>
<term>Carcinome endométrioïde</term>
<term>Protéine p53 suppresseur de tumeur</term>
<term>Tumeurs de l'endomètre</term>
<term>Tumeurs kystiques, mucineuses et séreuses</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
<term>Neoplasms, Cystic, Mucinous, and Serous</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
<term>Neoplasms, Cystic, Mucinous, and Serous</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Adénocarcinome à cellules claires</term>
<term>Carcinome endométrioïde</term>
<term>Tumeurs de l'endomètre</term>
<term>Tumeurs kystiques, mucineuses et séreuses</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénocarcinome à cellules claires</term>
<term>Carcinome endométrioïde</term>
<term>Facteurs de transcription</term>
<term>Inhibiteur p21 de kinase cycline-dépendante</term>
<term>Protéine p53 suppresseur de tumeur</term>
<term>Protéines proto-oncogènes c-mdm2</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Tumeurs de l'endomètre</term>
<term>Tumeurs kystiques, mucineuses et séreuses</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma, Clear Cell</term>
<term>Carcinoma, Endometrioid</term>
<term>Endometrial Neoplasms</term>
<term>Neoplasms, Cystic, Mucinous, and Serous</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cell Line, Tumor</term>
<term>Female</term>
<term>Gene Silencing</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Neoplasm Grading</term>
<term>Neoplasm Invasiveness</term>
<term>Phosphoproteins</term>
<term>Prognosis</term>
<term>Proportional Hazards Models</term>
<term>Signal Transduction</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Extinction de l'expression des gènes</term>
<term>Femelle</term>
<term>Grading des tumeurs</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Invasion tumorale</term>
<term>Jeune adulte</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles de hasards proportionnels</term>
<term>Mutation</term>
<term>Phosphoprotéines</term>
<term>Pronostic</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The morphological classification of high-risk endometrial cancer is of limited prognostic value. Recent attempts to stratify tumours according to molecular signatures have shown considerable promise. Here we attempted to further refine molecular classifications using markers of the p53 pathway.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Grand Manchester</li>
<li>Groningue (province)</li>
<li>Hollande-Méridionale</li>
<li>Ontario</li>
</region>
<settlement><li>Groningue</li>
<li>Groningue (ville)</li>
<li>Leyde</li>
<li>Londres</li>
<li>Manchester</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Groningue</li>
<li>Université de Manchester</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Bosse, T" sort="Bosse, T" uniqKey="Bosse T" first="T" last="Bosse">T. Bosse</name>
<name sortKey="Stelloo, E" sort="Stelloo, E" uniqKey="Stelloo E" first="E" last="Stelloo">E. Stelloo</name>
</noCountry>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Edmondson, R J" sort="Edmondson, R J" uniqKey="Edmondson R" first="R J" last="Edmondson">R J Edmondson</name>
</region>
<name sortKey="Crosbie, E J" sort="Crosbie, E J" uniqKey="Crosbie E" first="E J" last="Crosbie">E J Crosbie</name>
<name sortKey="Kaufmann, A" sort="Kaufmann, A" uniqKey="Kaufmann A" first="A" last="Kaufmann">A. Kaufmann</name>
<name sortKey="Kitchener, H C" sort="Kitchener, H C" uniqKey="Kitchener H" first="H C" last="Kitchener">H C Kitchener</name>
<name sortKey="Nickkho Amiry, M" sort="Nickkho Amiry, M" uniqKey="Nickkho Amiry M" first="M" last="Nickkho-Amiry">M. Nickkho-Amiry</name>
<name sortKey="Powell, M E" sort="Powell, M E" uniqKey="Powell M" first="M E" last="Powell">M E Powell</name>
</country>
<country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Nijman, H W" sort="Nijman, H W" uniqKey="Nijman H" first="H W" last="Nijman">H W Nijman</name>
</region>
<name sortKey="Creutzberg, C L" sort="Creutzberg, C L" uniqKey="Creutzberg C" first="C L" last="Creutzberg">C L Creutzberg</name>
</country>
<country name="France"><noRegion><name sortKey="Leary, A" sort="Leary, A" uniqKey="Leary A" first="A" last="Leary">A. Leary</name>
</noRegion>
<name sortKey="Auguste, A" sort="Auguste, A" uniqKey="Auguste A" first="A" last="Auguste">A. Auguste</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mileshkin, L" sort="Mileshkin, L" uniqKey="Mileshkin L" first="L" last="Mileshkin">L. Mileshkin</name>
</noRegion>
<name sortKey="Pollock, P" sort="Pollock, P" uniqKey="Pollock P" first="P" last="Pollock">P. Pollock</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Mackay, H J" sort="Mackay, H J" uniqKey="Mackay H" first="H J" last="Mackay">H J Mackay</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000828 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000828 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28511869
   |texte=   Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28511869" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.

Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.